Estogelcontains Estradiol which belongs to Estrogen derivative. It contains estrogen hormone (estradiol) which is absorbed through the skin into the bloodstream. It works by replacing estrogen that is produced by the body. This medicine is used after menopause to reduce moderate to severe hot flashes and treats moderate to severe menopausal changes in and around the vagina. It provides systemic estrogen therapy by releasing estradiol, the major estrogenic hormone secreted by the human ovary.  Endogenous estrogens are responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics.
Estradiol is the primary estrogen secreted prior to menopause. ESTO is absorbed through the skin and enters into the bloodstream which helps to reduce certain symptom of menopause like hot flashes, vaginal dryness, burning, and irritation. Always use this medicine exactly as instructed by your doctor. Before using this medicine, tell your doctor if you have liver, kidney or heart problems and if you are pregnant or breastfeeding. It is not recommended for use in children. The common side effects are breast pain, headache and nausea and vomiting.