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Janumet is a brand name for a medication that contains a combination of two active ingredients: sitagliptin and metformin. It is primarily used for the management of type 2 diabetes mellitus.


Sitagliptin: Sitagliptin belongs to a class of medications known as dipeptidyl peptidase-4 (DPP-4) inhibitors. It works by increasing the levels of incretin hormones in the body, which help to stimulate the release of insulin from the pancreas and reduce the production of glucose by the liver. By enhancing insulin secretion and reducing blood glucose levels, sitagliptin helps to improve glycemic control in individuals with type 2 diabetes.


Metformin: Metformin is a biguanide medication that helps to lower blood glucose levels by decreasing the production of glucose by the liver and increasing insulin sensitivity in peripheral tissues such as muscle and fat. It also helps to improve the uptake and utilization of glucose by cells in the body. Metformin is often considered a first-line treatment for type 2 diabetes and is commonly used in combination with other antidiabetic medications.


Janumet is available in tablet form for oral administration. The dosage and frequency of administration may vary depending on factors such as the individual's blood glucose levels, kidney function, and response to treatment. It is usually taken with meals to reduce the risk of gastrointestinal side effects.

Common side effects of Janumet may include diarrhea, nausea, vomiting, abdominal discomfort, headache, and upper respiratory tract infections. These side effects are often mild and transient, but if they persist or worsen, it's important to consult with a healthcare professional.


Janumet is typically used as part of a comprehensive treatment plan for type 2 diabetes, which may include dietary modifications, regular physical activity, and other medications as needed. It's important to use Janumet only as prescribed by a healthcare professional and to attend regular follow-up appointments for monitoring of blood glucose levels and kidney function.


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